Dimethyl fumarate abrogates dust mite‐induced allergic asthma by altering dendritic cell function

Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.

Airway DCs play a crucial role in the pathogenesis of allergic asthma, and interfering with their function could constitute a novel form of therapy. The sphingosine 1-phosphate receptor agonist FTY720 is an oral immunosuppressant that retains lymphocytes in lymph nodes and spleen, thus preventing lymphocyte migration to inflammatory sites. The accompanying lymphopenia could be a serious side ef...

Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function

Mesenchymal stem cells (MSCs) have been investigated in the treatment of numerous autoimmune diseases. However, the immune properties of MSCs on the development of asthma have remained to be fully elucidated. Airway dendritic cells (DCs) have an important role in the pathogenesis of allergic asthma, and disrupting their function may be a novel therapeutic approach. The present study used a mous...

Allergic contact dermatitis to dimethyl fumarate in footwear.

Sample 1: insole from black boot 120 Sample 2: tissue lining leather of black boot 640 Sample 3: insole from red boot 11 Sample 4: tissue lining leather of red boot 1.3 or leather sofas and armchairs manufactured in China. This substance has a wide-spectrum biocide activity and it is contained in paper bags, and progressively it can evaporate and contaminate the leather, textiles, food, cosmeti...

Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic Asthma

Dendritic cells (DCs) are highly specialized in antigen presentation and play a pivotal role in the initiation, progression, and perpetuation of adaptive immune responses. Emerging immune pathways are being recognized increasingly for DCs and their subsets that differentially regulate T lymphocyte function based on the type and interactions with the antigen. However, these interactions not only...

Persistent shoe dermatitis caused by dimethyl fumarate.